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This combined study design allowed us to define a detailed map of linkage disequilibrium of the NATs region as well as to perform a number of sequence-based neutrality tests and the long-range haplotype (LRH) test.
We used a combined study design to test the effect of clinical teaching on moral reasoning.
To test the causative relationship between clinical part of the medical curriculum and the development of moral reasoning, we used the combined study design derived from Schaie's description of a general model for study of developmental problems [14].
Consequently, a combined study design with action research and SD should be realised to evaluate the contribution of SD in a broader sense.
Furthermore, the ratio of sparsely to densely sampled individuals in a combined study design alters the precision of the parameter estimates.
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Heterogeneity was further reduced when we combined studies by design type.
All analyses were conducted using the random-effects model (inverse of variance method), as we combined studies with different methodological design and assumed that the true effect size varied from study to study [ 29].
Because the samples were combined, the study design did not permit examination of pouch-to-pouch variation during the day.
Discussion: The survey highlights that obtaining regulatory agreement for the proposed combined SP/Tox study designs may be useful before study conduct in some cases.
This applies when combing multiple studies each with a case-cohort design, but also when combining studies of different designs.
Other limitations include combining study protocols that were of differing designs and lengths and pooling clinical studies that were conducted over a period of many years.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com