This included the 10 EM discovery GWAS cohorts and 3 of the 4 replication cohorts, giving a combined sample size of 5205 EM cases and 16926 controls.
For this reason, we grouped the sites into 21 clusters with less variable combined sample size by pooling data from neighbouring sites so that each cluster included at least 25 samples.
The array had 34 elements, representing the combined sample size (16 hdp2 and 18 OreR samples).
As shown in Table 1, motility is the endpoint representing the greatest combined sample size for both in vivo and in vitro studies.
Two studies [ 21, 22] evaluated the efficacy of oral gabapentin as an adjunct to other AEDs, giving a combined sample size of 28 dogs.
Six studies [ 15, 26, 27, 29- 31] evaluated the efficacy of primidone as a monotherapy agent, giving a combined sample size of 103 dogs.
Two prospective studies evaluated the efficacy of oral gabapentin as an adjunct to other AEDs, giving a combined sample size of 28 dogs [ 44, 89].
Seven studies [ 11, 14, 15, 26, 27, 31, 36] evaluated the efficacy of phenobarbital as a monotherapy agent, giving a combined sample size of 269 dogs.
Three studies [ 12, 16, 23] evaluated the efficacy of levetiracetam as an adjunct to other AEDs, giving a combined sample size of 71 dogs.
For the combined sample size of 869 women, the proportion of 44% considered to be HIV-positive mirrors the national HIV prevalence rate.
