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Our results tended to show that replacing traditional pBLUP genetic evaluations by genomic evaluations in a breeding scheme organized around the combined phenotyping of candidates and sibs could result in more improvement in terms of accuracy of EBV, annual genetic trends and inbreeding than increasing the number of sibs phenotyped for trait 2 while retaining traditional evaluations.
For sire lines, Tribout et al. [ 7] estimated that replacing pBLUP evaluations by genomic evaluations in a breeding scheme based on the combined phenotyping of candidates and a limited number of sibs of the candidates could increase the annual genetic trend for the population breeding goal by approximately 30% through greater accuracy, while substantially reducing the rate of inbreeding.
Our results show that genomic selection could substantially increase genetic gains achieved in a purebred pig sire line breeding scheme organized around combined phenotyping of candidates and sibs with pBLUP evaluations, while significantly reducing the annual increase in inbreeding in the population.
The objective of this study was to compare the efficiency – in terms of annual genetic trends and annual increases in inbreeding – of a traditional pig sire line breeding scheme based on pBLUP genetic evaluation and the combined phenotyping of candidates and their sibs, with that of a genomic breeding scheme involving the same overall cost.
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No SNP showed any association with the combined phenotype of extrapulmonary TB compared to pulmonary TB in either ethnic group.
These myotubes exhibited caffeine-induced Ca2+ transients that consisted of Ca2+ oscillations and the sustained Ca2+ rise, which correspond to the combined phenotype of cells expressing the individual isoforms (Fig. 5B).
However, the rs6234 G-allele showed a significant association with increased risk of combined phenotype of obesity and overweight (OR 1.21[1.03 1.43], P = 0.0193) and a trend toward association with obesity (OR 1.25[0.98 1.61], P = 0.08) in men, but not in women (P≥0.29).
For this study, we combined phenotypes from many thousands of animals with genotypes of their ancestors.
The variant alleles occur with a combined phenotype frequency of about 25%to30%0% in the Caucasian population [ 10, 11].
Thus, when combined, phenotypes generated by each variable independently serve to restore behavioural and anatomical alterations in mice.
To date, most ADHD research has focused on the combined phenotype or has not differentiated among the three phenotypes (Aguiar et al. 2010).
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