Sentence examples for combined mutations of from inspiring English sources

Using reverse genetics, combined mutations of Q253H and A284T could adapt vvIBDV to non-permissive CEF cells (rGx-F9VP2) but any single mutation could not.

Similarly, plants carrying the combined mutations of three cytokinin receptor genes, AHK2, AHK3, and CRE1/AHK4, bear seeds that are more than twice as large as those of wild-type plants, primarily due to an increase in the size of their corresponding embryos.

Genetic interaction analysis, in which the combined mutations of two genes exhibit phenotypes significantly different from the single mutation of either one [1], is a powerful tool allowing biologists to investigate the genetic components of an organism [2].

PIK3R1 mutations as well as combined mutations of the three genes studied were also found to be mutually exclusive with PTEN underexpression (p = 0.00016).

Combined mutations of I127A/I133A/E137A and PR2, which also contributes to interaction with PTEN, resulted in further inhibition of PTEN binding, indicating that these residues are cooperative in binding PTEN.

Mutation of a promoter proximal Sp1 site did not show significant effects on its own, but combined mutations of the Sp1 and both AP1 sites fully suppressed Smad4 effects on basal and TGFβ-induced promoter activities.

Employing missense mutations in these lengthy genetic schemes is risky because if one of the mutations is not effective, it may be sufficient to limit the effect of the combined mutations on function.

The combined mutation of the HRE and one of the SBE nearly abolished promoter activity.

The combined mutation of both motifs inhibited promoter reporter activity most strongly.

In both cases, only the combined mutation of all five phosphorylation sites caused a slight decrease in Nrf2 transcriptional activity (Figure 2A and 2B).

Combined mutation of Ser-36 and Ser-41, in the ATF1S36/41A mutant totally abolished the ATF1 electrophoretic mobility shift (Fig. 1D).