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In general, the effects of induced hypothermia have been investigated in models with isolated haemorrhagic shock or in combined models with additional trauma load (Additional file 2: Table S2).
To implement a combined discrete event and discrete time simulation such as submarine diving simulation in a distributed environment, e.g., in the High Level Architecture (HLA)/Run-Time Infrastructure (RTI), a HLA interface, which can easily connect combined models with the HLA/RTI, was developed in this study.
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In addition, the forecasting results of a combined model with inappropriate weights may be less reliable than those of single models.
Time-dependent ROC curve was used to compare the prognostic validity of the combined model with each factor alone model.
18 evaluations were conducted alongside clinical trials, four were part of observational studies, five were hypothetical decision-analytic models and one combined modelling with within-trial analysis.
We tested this conjecture with a corresponding simulation, which revealed that only the combined model with product inhibition and substrate competition matches the experimental observations.
Also in this context, the benefit of using a combined model with both miRNA and gene markers for prediction of patient prognosis was confirmed (Supplementary Table 6).
The third step was to validate the combined model with 12 months of morbidity data from January 2012 to December 2012 and to further forecast the incidence of hepatitis E in 2013.
Of note, the combined model with NT-proBNP and CCS without P-OPG already had an AUC of 0.84 and it is therefore difficult to increase the area further.
By contrast, the ensembles exhibiting the highest predictive power on the test set were obtained when combining models with high and low predictive ability.
The structure of novel forms of carbon nanostructures (Haeckelites) is investigated combining modeling with experimental data.
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