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Recently, the in vivo stiffness was characterized using combined imaging techniques and inverse finite element analyses.
The development of new combined imaging techniques however also requires the development of the respective hybrid imaging agents that are suitable for all involved imaging modalities.
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Advances in single-cell methods that combine imaging techniques with metabolic analyses, such as nanometer-scale secondary ion mass spectrometry and Raman microscopy, permit the visualization of uptake and distribution of substrates from the environment as well as measuring the rates at which substrates are acquired (Lechene et al. 2007).
This finding is important for future clinical evaluations of Raman spectroscopy for MPS disease characterization, as such a clinical system will benefit from a deeper interrogation depth and possibly a combined imaging technique to allow determination of subsurface anatomy.
We believe that the modular approach, combined with imaging techniques and other analytic tools such as ELISA, offers a powerful system for studying 3D biology in a number of different contexts.
In previous research, liposomal delivery of therapeutic agents has been combined with imaging techniques such as magnetic resonance imaging (MRI) [13 20], positron or single-photon emission tomography (PET/SPECT) [21 23] and fluorescence [13 17].
Here, we have combined confocal imaging techniques and specific inhibition of endogenous GRK isoenzymic activities to examine the interaction between GRKs and the native ETAR population in isolated, cultured mesenteric smooth muscle cells (MSMCs), a widely studied model of systemic resistance arteries.
The present study relies on an integrated experimental approach combining several imaging techniques at microscopic and macroscopic scales, ranging from optical and electron microscopy to X-ray and elemental imagings.
In studying both nonreacting flows and flames it is useful to combine various imaging techniques to gain information that is not available from either instantaneous or time-averaged point measurements.
Recently, multimodality molecular imaging combining several imaging techniques has attracted much attention in basic scientific and clinical research.
Combining several imaging techniques provides complementary information which helps in interpreting and understanding the findings of each modality.
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