The paucity of temporally-resolved localities with diverse Ediacaran assemblages, combined with difficulties associated with differences in taphonomic regimes before, during, and after the transition hinders this evaluation.
The high costs and risks of drug development, combined with difficulties in conducting clinical trials in small patient populations and the small market size, discourage the pharmaceutical industry from developing drugs for these rare diseases [ 2, 6].
According to Thorpy et al. (2000), sleep disruption combined with difficulties in tolerating sedentary activities can compromise an individual's lifestyle, perhaps leading to job loss and problems with relationships.
The combined item difficulty and discrimination across all subject populations were generally within the range of desirability (Crocker and Algina, 1986; Haladyna, 2004; Figure 3): difficulty (P) ranged from 0.08 to 0.84 (lower values are more difficult items), with a mean P of 0.51 (±0.049 SEM); discrimination (D) ranged from 0.11 to 0.82, with a mean D of 0.50 (±0.048 SEM).
On the contrary, it also seems plausible to assume that integrated scenarios do combine the difficulties of both components, and in addition, might add new complexities and 'muddling' to the scenario construction process in form of further (not explicit) assumptions.
Obtaining an effective prophylactic or therapeutic vaccines against prion diseases combines the difficulties of developing vaccines against persistent infections, and those inherent to immunotherapy against self-antigens.
Its difficulties, combined with the challenges of the staging, made him insecure.
The team's difficulties, combined with the beating the bullpen had taken the past four games, magnified the need for a change.
This is due to rampant budget deficits, combined with the difficulties of quashing inflationary expectations after a high-inflation period: prices rose twice as fast during the 1980s.
But now some defense officials are saying the occupation force's state of siege, combined with continuing difficulties in restoring services in Baghdad, is making Iraqis increasingly hostile toward those who are supposed to be their liberators.
