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An investigation of these combined data was conducted, and an attempt to model the resulting structures on the basis of the primary results was made using generalized toolboxes (essentially, "Ircamdescriptor" from Peeters [15] and "Auditory Toolbox" from Slaney [16]) in order to unify and in some cases to improve the description of the initial data.
In fetal samples the most significant association in the combined data was rs854552 in the paraoxonase 1 gene (PON1) (combined allele p = 8×10−4).
The combined data was represented by relatively smooth curves.
Positive predictive value of the combined data was 0.80.
The combined data was tested for normality using the Anderson-Darling test.
The right-left combined data was normally distributed as revealed by Kolmogorov-Smirnov test of normality.
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For five countries, where both regional and combined-regional data were presented, only the combined data were used in this analysis.
Summary statistics of combined data were performed when possible.
The combined data are provided as Swarm Level 1b, which means calibrated time series of Swarm observations.
Combined data were analysed in Microsoft Excel (Mac 14.4.3) and R Studio with results plotted in GraphPad Prism 6 (Mac) and R (3.3.1 Unix; r-project.org).org
The combined data were converted to DTA format [35] and supplied to the XProteo search engine (www.Xproteo.com).
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