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The combined binding of scV/Tc to both macrophages and endothelial cells in plaque neoangiogenesis in theory provide two targets for scV/Tc binding to boost plaque signal [8],[8]],[8]].
Nevertheless, there is no overall correlation of combined binding of CTCF and Oct4 in the genome [26].
Peptides 4, 10, 19 and 24 all face the cavity between the actin-binding domain and the central rod domain, potentially forming a combined binding site for HAMLET.
Therefore, we wanted to know the frequency of combined binding sites for CTCF and the thyroid hormone receptor in the genome.
'Auto-FACE' is more useful in distinguishing the binding site residues from the large number of perturbed residues, which resulted because of combined binding and allosteric effects.
Since HLA-B57 and B58, and HLA-B35 and B53 are known to have similar binding motifs [38] we generated combined binding logos for the HLA alleles with low and high RH (see Figure 3).
Similar(40)
By combining binding determinants from both substrates into a single molecule, the effective affinity and selectivity for the target is dramatically increased.
Therefore, we used a factor analysis approach using a principal component analysis (PCA, total variance used) as a reduction method [64] to combine binding data from the two radiotracers into a single factor.
Although applications that combine binding site prediction with other data sources, especially "phylogenetic footprinting," are plentiful (see e.g [46], [47], or [29], [48] for review), we are not aware of other probabilistic frameworks for TF binding modeling that can combine several additional data sources at the genome level.
We take a further step to combine binding sites detected from both strands.
Combining binding by either TF with HMs such as H3K27ac or H3K4me1 gave only a very small increase in power.
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