Sentence examples for combined alterations from inspiring English sources

It should be noted that the K98A/R185A mutant also exhibits reduced BER activities, implying that the combined alterations of these two amino acid residues may result in defective folding and decreased protein stability.

Our results demonstrate that beyond their individual contributions, the combined alterations of EGFR, p53 and PTEN together cooperate to bestow features of cellular transformation on MCF10A cells.

The combined alterations in these various pathways seem to favor protein aggregation and demyelination, paving way for an auto-catalytic loop and thus contributing to disease advancement.

Because assay-related single cell variation will multiply its negative effects, the more genomic loci of a cell are investigated, such a high reliability of each assay was needed to demonstrate combined alterations of the two genes.

Thus, 41% of tumours with altered p53 also showed downregulation of PTEN and this combined alteration of p53 and PTEN was associated with poor patient outcome [ 35].

Combined alteration of all three PGs was found to be a reliable predictor of shorter survival.

Several years ago, Per Björntorp proposed the hypothesis that the combined alteration of the glucocorticoid pathway and androgens associated with abdominal obesity may have a role in the pathophysiology of metabolic syndrome and insulin resistance (Fig. 2).

Collectively, these data suggest that compromised insulin secretion in Rfx6-deficient β cells is the consequence, at least in large part, of the combined alteration of key steps in glucose signaling due to a failure of Rfx6 to directly promote the expression of key genes.

Other components of SAGA and NuA4 did not cluster within this leaf suggesting that the effects of tra1- L3733A result from the combined alteration of SAGA and NuA4 complexes and/or that Tra1 has one or more roles outside these complexes.

Previous studies of trisomic mice for the same region (Ts1Yah) showed a complex cognitive phenotype that combined alteration in specific domains that are affected in well-characterized DS models such as nonassociative learning and short-term spatial and recognition memory (Lopes Pereira et al. 2009).

Category I/I indicates problems that are almost the same as the bases, D/I indicates problems generated by altering the situations of the bases, I/D indicates problems generated by altering the solutions, and D/D indicates problems generated by combining alterations in both situations and solutions.