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This study was undertaken with HEWs who were participating in the COMBINE trial.
We sought, if appropriate, to combine trial results in a meta-analysis.
The consistency of results across trials may influence the decision of whether to combine trial results in a meta-analysis.
The reviewers did not combine trial data in a meta-analysis because of heterogeneity in population, intervention, and outcome assessment.
These modules are based on the manual and procedures for the Combined Behavioural Intervention (CBI) as developed and tested in the COMBINE trial.
The most rigorous study of cost-effectiveness of alcoholism treatment, the COMBINE trial, found that treatment was cost-effective, especially pharmacotherapy with medical management (Zarkin et al. 2008, 2010).
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If the average treatment effect is not clinically meaningful, we will not combine trials.
If the average treatment effect was not clinically meaningful, we did not combine trials.
Since single trial volumes cannot be increased indefinitely, it becomes necessary to combine trials for further gains in statistical power.
Meta-analysis has developed to be a widely used tool to combine trials evaluating the same intervention.
We used random-effects meta-analyses to combine trials and quantified heterogeneity with the I statistic (Higgins et al, 2003).
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