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Based on the COMBINE model, together with Brownian dynamics simulations to compute diffusional association rate constants, several mutants were designed to have higher binding affinities than the wild-type proteins.
There have been a handful of methods proposed [10, 11] that combine model adaptivity with spatial analysis.
To benefit from these methods, for a large system, one can combine model checking with our approach.
To combine model simplification with sensitivity analysis is a way to investigate the structure of complex biological networks.
In this way we have been able to produce probabilistic assessments of different control strategies that combine model assumptions, uncertain information about parameter values found in the literature and limited data on within-herd prevalence.
As Additional file 1: Figure S1d demonstrates, this change does not alter substantially the systems dynamics as the Nanog promoter activity can be obtained by scaling Additional file 1: Eq. (S17) the activity of model C. Finally, we combine model D with model B to see if NANOG autorepression can further promote the transformation of the "ON" fixed point into a spiral.
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You want to combine models that complement one another.
In our approach, we combine models of different natures.
A fingerprint is an attempt to combine models of climate change with observed data.
In our investigation we combine modeling, simulations, dynamical systems tools and dynamic clamp experiments.
Combining Model Checking and Runtime Verification for Safe Robotics.
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CEO of Professional Science Editing for Scientists @ prosciediting.com