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Next-generation therapies that combine cells with biomaterials may provide improved outcomes.
The dogma in tissue engineering is to combine cells, matrices and signalling molecules to create a regenerative matrix.
Tissue engineering approaches that combine cells, scaffolds, and stimulatory cues hold considerable potential for regenerating functional bone.
The traditional approach to tissue engineering is to combine cells with biomaterial scaffolds in order to create a template for tissue formation.
Herein, we report two main strategies to combine cells with biomaterials: cells are either seeded onto prefabricated hydrogels films (2D), or encapsulated during hydrogel microcapsules formation (3D).
The basic idea of TE is to combine cells with putative stem cell properties with extracellular matrix components, growth factors and supporting matrices to achieve independently growing tissue.
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Furthermore, multifunctionality of the materials will combine cell and tissue specific properties with specific drug delivery concepts and diagnostic methods.
It may be possible to combine cell-surface immunophenotyping with intracellular FACS analysis to identify cell-surface signatures of specific cell types and subpopulations therein.
To improve therapeutic effects, an alternative strategy is to combine cell transplantation with gene therapy.
Overall, we tried to combine cell therapy and biomaterial, specifically, which was hDFCs implantation combined with longitudinal aligned electrospun PCL/PLGA material.
The highly innovative therapy tested in the TREAT-ME1 study utilizes the patient's own MSCs to combine cell and gene therapy at a high pharmaceutical quality level.
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