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The solubility parameters of polymer and surfactant combinations were calculated using the following equation: (3) δ 1,2 = V 1 ′ δ 1 + V 2 ′ δ ρ 2, where V′ is the volume fraction of each compound.
GAM models for all individual intron/mRNA combinations were calculated using a Gaussian distribution with 'identity' as the link function, and the method 'GCV.Cp' was used for estimating the smoothing parameters of the log2 fold-changes for the mRNAs.
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The combination index (CI), which is used to evaluate the effect of two-drug combinations, was calculated using the Chou-Talalay method [ 20].
The mean of the jackknife Pearson correlation coefficient of the merged and pre-processed expression values for all gene pair combinations was calculated using the bootstrap library implemented in R.
In this module (Fig. 1), genome-wide segmental LogRatios for each of the (N !)/(2 * (N − 2) !) random normal normal combinations are calculated using read depth comparison and circular binary segmentation [ 30].
Synergism of drug combination was calculated using CalcuSyn 2.1 (Biosoft, Cambridge, UK).
In this analysis, asthma incidence for each sex-cohort combination was calculated using the outcome at each cycle of follow-up.
The risk of RA associated with carriage of PADI4_94, PTPN22 and SE risk alleles (1 or 2 copies) alone and in combination was calculated using logistic regression.
Whether the anticipated combination effects were calculated using the data from the concurrent studies or using the pooled data sets including the historical data had little influence on the quality of the prediction.
TNBC cells were pretreated with Noscapine or Doxorubicin or combination and combination index values were calculated using isobolographic method.
For two-phrase combinations, expected values were calculated using the random model.
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