Incorporating adaptive control with anti-windup (AW) compensators can provide a convenient combination to counteract the challenge.
The severity of ALS and the lack of effective therapeutic strategies are driving efforts to explore agents, applied either separately or in combination, to counteract disease symptoms.
The benefits of combination therapy to counteract quasispecies adaptability have been supported by both, theoretical studies on virus population dynamics, and clinical observations ([57] [63], among other studies).
A growing number of research groups have investigated the efficacy of supervised exercise training interventions (aerobic, resistance, or combination training) to counteract therapy-induced poor cardiorespiratory fitness both during and following the completion of adjuvant therapy.
In the combination, calcipotriol was not able to counteract the betamethasone-induced suppression of HA secretion in fibroblasts in line with the lack of effect by calcipotriol mono-treatment (Fig. 3a).
Therapies aimed at blocking TGF-β can be administered in combination with CAR T cells engineered to counteract the suppressive tumor microenvironment.
Ketamine is different in part because it's most effective as an IV drug, one that must be administered in a hospital or clinic, often in combination with other strong drugs like Versed, to counteract its hallucinogenic effects.
Thus, the combination of these synaptic inputs was sufficient to counteract the NT-3-induced decrease in excitability to permit treadmill-assisted stepping.
The current clinical practice based on drug combination therapeutic regimens represents the most effective approach to counteract drug resistance.
Strategies to counteract TMZ resistance include its combination with poly(ADP-ribose) polymerase inhibitors (PARPi), which hamper the repair of N-methylpurines.
In conclusion, the combination of TMZ with PARPi is a valuable strategy to counteract chemoresistance of GSCs which contributes to treatment failure and tumor recurrence in GBM patients.
