Therefore, there are eight possible combinations of specificity for alignment A, alignment B or the consensus (Fig. 1B).
The ROC curve represents all possible combinations of specificity and sensitivity for each predictive model, so ROC-AUC measures its overall performance.
Although a few multicatalytic enzymes with the former combination of specificities have been described previously, e.g. [27], [28], this is the first report of the latter combination.
Instead, with its combination of specificity and mystery, a local police report from the time reads like something out of Mr. Kundera's writing.
Complete AUC were then computed as well as the cut-off corresponding to the best combination of specificity (SP) and sensitivity (SE).
Advances in genetic engineering and ex vivo expansion techniques have sculpted cellular therapy products to optimize the combination of specificity and toxicity.
The combination of specificity, the possibilities of endogeneous synthesis or exogenous delivery, and the capability to be adapted for the destruction or modification of any RNA species make ribozymes extremely attractive genetic tools and potential therapeutic agents.
The unique combination of specificity and plasticity in TRiC substrate binding may diversify the range of motifs recognized by this chaperonin and contribute to its unique ability to fold eukaryotic proteins.
The results of this study reveal a hitherto unappreciated combination of specificity and adaptive plasticity inherent to PDZ domain recognition.
A comparative statistical analysis of affinity-ranked artificial and natural ligands yielded a comprehensive picture of known and novel PDZ ligand specificity determinants, revealing a hitherto unappreciated combination of specificity and adaptive plasticity inherent to PDZ domain recognition.
