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By representing proteins folds and functions in form of a graph connected by the prototypes one can proceed to explore the emergence of protein functions as combinations of prototypes.
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This set delineates evolutionary connections between major functions and illuminates how folds and functions emerged in pre-domain evolution as a combination of prototypes.
We illustrate how a functional domain emerges as combination of prototypes by the example of Glycosyltransferase superfamily (orange oval in Fig. 4). Figure 5 shows glycogen synthase (PDB 1rzu), which catalyzes the elongation of alpha-1,4-glucose backbone.
The proposed model and architecture were validated using a combination of prototyping and traffic simulation traces, and the obtained results are very promising.
Combinations of these prototypes were then used to make a further 108 sculptures in collaboration with traditional Chinese craftsmen.
In order to draw a picture of folds and functions emerging as combinations of EFLs, prototypes of the EFLs will be derived and the corresponding EFLs will be detected in proteins with known biochemical functions.
Illumination impacts are reduced by generating the virtual prototypes from the linear combination of collected prototypes.
The combination of the prototype demonstration, and former id founder and Doom creator John Carmack explaining his vision of where he sees the entire Oculus project headed "pretty much convinced them on the spot," Iribe tells me.
We built this model by a combination of rapid prototyping techniques and tested it to demonstrate its wall deformation and pump function.
Based on combination of the prototype microelastic brittle (PMB) model and the viscoelastic Kelvin Voigt model, we propose a peridynamic (PD) rate-dependent constitutive equation and a new interlayer bond describing interlayer interactions of fiber reinforced composite laminate.
Interface design was developed using a combination of paper prototyping [ 17] and use cases.
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