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However, various combinations of outcome measures showed worse patient outcomes across the eight hospital sites [ 10].
Thus, multiple moderators may be tested in combinations to explore complex clinical prediction rules and against complex combinations of outcome measures, as long as the tested prediction are specific.
The results warrant further exploration into different perspectives and relevant combinations of outcome measures including the use of health resources, drugs and cost-effectiveness to help understand the relevance of IM in primary care.
The set-up is usually summarized by a four-fold table where each cell represents the absolute number of individuals for the different combinations of outcome (disease D+ vs. no disease D-) and test result (positive T+ vs. negative T-) (see Additional file 1: Appendix A, Table A1).
A saturated logistic regression model for the situation where data were available for all four combinations of outcome and missing data indicator is not identifiable here, because we do not observe data where the missing data indicator is 0. Hence the model identification must come from the form of model (2), which assumes linearity and no interactions.
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A measure developed by Van Lange and colleagues (23) to measure social value orientations by using a series of decomposed games, involving choices among combinations of outcomes for oneself and for another person, was adapted in this study.
Further, sensitivity analysis was used to assess the range of possible combinations of outcomes.
The groups did not show any difference with respect to these individual outcomes or combinations of outcomes (18).
Next, participants were asked to rate 14 pairs of combinations of outcomes, where each combination consisted of two or three outcomes.
Sensitivity, specificity and predictive values for ALSPAC outcomes and combinations of outcomes were calculated using GP-recorded diagnosis as the gold standard.
Adjustment by gender caused relative changes of 10% or less in the ORs for both mental and physical impairment, and significance for gender of more than 0.20, in all but two combinations of outcomes and impairment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com