He is noted for his cancer prevention studies with nutrients, other dietary constituents and combinations of agents.
We are testing the immunotherapeutic efficacy of combinations of agents that enhance activation of cytotoxic cells, prevent inhibition of the cells, and block desensitization of NK cells.
We must intervene with more effective agents or combinations of agents and do it earlier in the process of carcinogenesis.
As a consequence, targeted treatment strategies may need to be altered to accommodate combinations of agents that target oncogenic pathways that are active at both the early and late stages of tumor development.
Increasingly, combinations of agents are being used to achieve synergistic inhibition of viruses, to delay resistance, and to decrease dosages of toxic drugs.
Based on the data observed in this study, the optimum combinations of agents were selenium, fosfomycin, methionine and taurine, and zinc, selenium, STS and methionine.
Mice were supplemented by gavage with various combinations of agents as designed in the orthogonal table once a day for nine days beginning two days before cisplatin administration.
This should promote the use of the PO-CRM in designing and conducting dose-finding Phase I trials of combinations of agents.
This paper presents the R package pocrm for implementing and simulating the partial order continual reassessment method (PO-CRM; [1,2]) in Phase I trials of combinations of agents.
This review discusses the MoA of these novel therapies and how a greater understanding of MoA may help to predict the range and type of side effects, develop combinations of agents with acceptable tolerability, enable a more rational approach to patient selection, and allow the development of effective side-effect management strategies.
