While the progressive nature of structural brain changes in schizophrenia is not yet fully understood, they are thought to be in some degree due to a combination of abnormalities of synaptic plasticity, abnormal brain maturation and distinct environmental factors [ 37].
However, in the present study, LossGain coding was applied only to see the combination of abnormalities displayed by the patients and no analysis was performed to differentiate between the groups.
These risk factors may include any combination of abnormalities in the blood vessel wall, abnormalities in the blood flow (as in immobilization), and abnormalities in the consistency of the blood.
CF lung disease is regarded as a combination of abnormalities in electrolyte transport, epithelial lining fluid (ELF) composition, pathogen clearance and inflammatory response that set in motion a self-perpetuating cycle of airway obstruction, chronic bacterial infection and inflammation.
Arrhythmia generation in the left atrium (LA) originates from a combination of abnormalities in impulse initiation, impulse conduction, or a combination of the two [ 11].
Besides disease developmental pathways where there appears to be some preferential combination of abnormalities, overall, there are some pathways that are recurrently deregulated by different mechanisms in myeloma.
However, CENP-F −/− hearts have a unique combination of abnormalities, including reduced mitotic activity during embryogenesis, loss of intercalated disc structure and disruption of costameres, that underlie the phenotype of dilated cardiomyopathy.
We speculate that the combination of abnormalities in fatty acid metabolism in MCDD mice leads to accumulation of FFAs within the liver that is disproportionate to the accumulation of triglycerides and predisposes MCDD mice to complications.
