However, synergistic combinations clustered around a GI50-value of 1µM for PI-103.
In particular, ratios were especially large for NZB mice (males and females), A/J mice (males and females), 129 males and B6 males, and in Figure 1, these strain-gender combinations clustered together in a single group.
In many cases, novel findings for previously unreported chemical target combinations clustered with known chemical target interactions.
Combination cluster defined by the presence of either BP or GL or both BP and GL were most prevalent (24%, 23% respectively).
Nobody has, and in the final last night Clay, like some loosely strung marionette, put his punches together in combination clusters and pummelled the Pole about the ring.
The prevalence of individual combinations was not reported but the age, gender and race adjusted rates of 7 recombined combination clusters.
Furthermore, four tumor samples (one from a mouse treated with CPT-11 alone and three from mice treated with the combination) clustered separately from the other CPT-11 treated animals.
Interestingly here, the biclustering results show that pancreatic endodermal transcriptional machinery may not be favored at the DE stage by the FGF2 + BMP4 combination although in our hierarchical clustering results FGF2 + BMP4 combination clustered with the other conditions that gave a better DE signature.
Even when clustering combinations yielded reasonable clustering (more than two clusters) the clusters had little separation and multiple contributing factors, i.e. large numbers of genes and clinical covariates that defined each cluster.
We also drew power contour graphs, showing combinations of cluster sizes and number of clusters leading to a pre-specified power, with type I error fixed at 5%.
In order to match clusters across trial sets, all possible combinations of cluster pairing in the two datasets were considered, and the one with the highest overlap proportion was used to calculate the similarity scores.
