Sentence examples for combination with substantial from inspiring English sources

The annotations were combinatorially performed by hydrogen rearrangement rules in combination with substantial manual curation.

Fragment annotation of ceramide [NS], the major ceramide class, was performed with the MS-FINDER program in combination with substantial manual curation (Fig. 2a).

In combination with substantial ICs (on average €20 395, 95% CI 18 278 to 22 617), this results in very high ICERs of about €750 000 per QALY gained.

Moreover, early entry in combination with substantial market share would render late entry irrelevant anecdotal evidence has it that doctors' brains, already saturated by existing brands, can be penetrated neither by late entrants' research and development activities nor by their marketing efforts.

Overall, the influence of severity on susceptibility of pretreated substrates to enzymatic hydrolysis was clearly discernable, showing co-hydrolysis to be a viable approach for identifying plant-pretreatment-enzyme combinations with substantial advantages for sugar production.

With optimised pulse plating parameters, and in some cases in combination with additives, substantial improvement of the deposit properties can be achieved.

While live leaf tissue before embedding (Fig. 3a) was characterized by an excellent signal-to-noise ratio showing several mini-rings per chloroplast, semi-thin section of embedded tissue exhibited a loss of YFP fluorescence in combination with a substantial increase in autofluorescence background (Fig. 3b) preventing the detection of FtsZ2 mYFP assemblies.

In summary, our data show that Wolbachia is maintained within our large outbred laboratory population (once it was established), because of the low fraction of uninfected ova from infected females in combination with a substantial level of CI.

When maximum uptake levels in the tumor are reached, in combination with a substantial clearance from non-target tissues, a small radiolabeled agent that is recognized by one arm of the bispecific antibody is given in a second phase.

In combination with a substantial mean incremental cost of €373 per patient (95% CI 279 - 475), this results in an unfavourable average ICER of €1 244 023 (95% CI 328 571 - 4 712 704) per QALY gained.

Moreover, recovery from fast inactivation slows for all tested Nav channel isoforms, and although these effects are subtle, the combination with a substantial shift in hNav1.1 activation voltage may help explain a decrease in neuronal excitability after administration of the drug.