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We go beyond the attributes that were find as the best combination to explore further possible relationships.
The ROC analysis was first conducted on individual markers and then in combination to explore the potential that a panel of markers can provide improved performance.
ROC analysis was first conducted on individual markers and then on their combination to explore the possibility of a marker panel to lead to improved performance.
Within this framework, polygenic modeling, as well as haplogroup and mtSNP association tests can be used singly or in combination to explore the relationship between mtDNA variation and a range of phenotypes in the context of mt-PheWAS.
We have used this combination to explore pertinent questions regarding the mtDNA bottleneck (and others have used a similar philosophy to numerically explore mtDNA point mutations [ Poovathingal et al., 2009]): we hope to convince the reader that such methodology may be appropriate to explore other problems involving stochastic biological systems.
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Using higher number of addresses (e.g. U=20) increases the computational cost of ReVS exponentially due to the exponential increase in the number of address combinations to explore.
Thus, multiple moderators may be tested in combinations to explore complex clinical prediction rules and against complex combinations of outcome measures, as long as the tested prediction are specific.
Unfortunately, investigating interactions with comprehensive association testing can result in much higher multiple hypothesis testing and increased Type-1 error, due to the number of n-wise combinations to explore.
Dacarbazine, dimethyltriazenoimidazole carboxamide (DTIC) which is also activated to form MTIC, was selected for clinical investigation in combination with olaparib to explore the combination's activity in melanoma.
The CONCERTO trial evaluated ascending doses of MTX in combination with adalimumab to explore the dose response of MTX and the risk benefit profiles of these doses of MTX in combination with adalimumab in patients with early, active RA.
We used p38 and JNK kinase inhibitors in combination with anisomycin to explore the relative contributions of p38 and JNK to the sensitization of cell death in infected cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com