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Additionally, increased intracellular accumulation of both drugs was observed in the combination setting.
Furthermore, in the in vivo DU145 xenograft PCa model, we clearly demonstrated delayed tumor growth in the combination setting.
Tz as a single agent exhibits little significant activity, but when used in a combination setting it has proved to be of significant therapeutic value [ 38].
As shown in Figure 3, within 24 h, both agents, among several pathways examined (data not shown), were able to modulate either AKT or ERK, depending on the cell line evaluated, with any interaction observed in the combination setting.
A suboptimal dose of Dt (5 mg/kg) was administered using a Q7D once a week for four weeks dose schedule in order for us to assess whether 267 contributed to improved outcomes in a combination setting.
A combination therapy approach provides an attractive option in the management of ER-/AR+ breast cancer, since it exploits the synergy between AR and MEK inhibitors and at the same time minimizes their potential toxicities by requiring a lower dose of each agent in the combination setting.
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The combination set him thinking.
The combination set the stage for two solid decades of deflation.
The U. S. Steel combination set a record that remained unbroken for more than half a century.
The results were compared by various program combination sets to analyze and determine the correlation of estimated energy use intensities (EUIs).
This paper proposes a new method for finding a suitable glass combination set for an advanced telephoto lens via a genetic algorithm (GA).
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CEO of Professional Science Editing for Scientists @ prosciediting.com