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Compared to the search query developed for the identification of prediction models in non-pediatric medicine [ 15], the present search strategy yielded a higher combination sensitivity and specificity by identifying 5 eligible prediction models without missing a citation, but at the expense of a higher number needed to read (NNR 93.2 vs. 74.4).
Data supporting the latter recommendation were not published before [ 3] but the present data support this recommendation as in early arthritis with RA as outcome, the best sensitivity-specificity combination (sensitivity 74 to 77%, specificity 48 to 52%) was present for morning stiffness enduring ≥30 minutes.
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In addition, we compared methods with only a few chosen parameter combinations; sensitivity analyses showed that the results were not sensitive to the smoothing parameter or the specification of correlations between streams.
To evaluate the effect of varying alignment parameter values on cladogram topology, independent analyses of the complete data set were performed for a range of parameter combinations (sensitivity analysis sensu [ 103]) under parsimony.
Drug-combination sensitivities again varied across the four cell lines; however, it appears that combinations of NB598 and 5-fluorouracil were typically synergistic, while combinations with carboplatin or paclitaxel were typically antagonistic.
Cut-offs with the best combination of sensitivity and specificity (mean of sensitivity and specificity >70%) were similar across studies.
Both works are done with a startling combination of sensitivity and panache.
He was an idealist who learned how to turn ideas into execution, with a combination of sensitivity and persistence.
An interim manager needs to handle challenging leadership situations with a combination of sensitivity and gravitas so they can integrate themselves into organisations and quickly engage a workforce.
He must have thought that Grant's character, in its combination of sensitivity, straightforwardness, and deep, internalized melancholy, was like his own.
Mr. Huebner played all these works with a combination of sensitivity and vigor that served Mr. Andriessen well.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com