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Combination selectivity was unaltered when two drugs have self self or additive interactions (e.g., methyl methanesulfonate methyl methanesulfonate, Fig. 3a, left).
In order to compare the observed selectivity of combinations with a null model, we approximated expected selectivity (selectivityexp) as the combination selectivity that would be observed if drugs A and B have additive interactions in both species (Fig. 3, middle column) (Supplementary Fig. 2, lower panel).
The model was able to reproduce the diversity of combination selectivity observed in ICcl (Figure 3).
Nor have previous models addressed key aspects of combination selectivity for ITD and ILD observed in the spiking responses of ICcl neurons.
In particular, models that explicitly include ICcl assume that combination selectivity for ITD and ILD is uniform over the population [24], [25], whereas experimental measurements reveal a diversity of responses to ITD and ILD in ICcl [7].
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The combination CAL + DYC had a higher selectivity score than the no drug condition, indicating that the combination selects for C. albicans, thereby validating the prediction of inverted selectivity under treatment with the CAL + DYC combination.
Pentamidine and staurosporine (PEN + STA) each preferentially inhibit C. albicans, and because they are synergistic only in C. albicans, their combination enhances selectivity for the growth of S. cerevisiae compared to either single drug (Fig. 3b, left).
Immunoadsorption possesses an attractive combination of selectivity and yield, and in some cases may replace many conventional purification steps with a single step.
Among the synthesized fluorescent probes, NCHN (N-3-carboxy propyl-4-hydroxy-1,8-naphthalimide) displayed the best combination of selectivity, sensitivity and ratiometric fluorescence response following UGT1A1-catalyzed glucuronidation.
In general, PTP substrate specificity is defined by a combination of selectivity in the catalytic region and the adjacent regulatory domains.
The reasons for this combination of selectivity and flexibility were then identified in single-crystal structure determinations of the [Ce HTCPB ⋅ xylene)] phases, denoted 3 P and 3 M, formed by loading pX and mX, respectively, into 3.
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