Sentence examples for combination screen from inspiring English sources

in vitro [73] Lymphoma Drug combination screen Screen of 500 compounds with ibrutinib revealed favorable combinations with inhibitors of PI3K signaling, the Bcl2 family, and B-cell receptor pathway in vitro [74] Various cancers Drug combination screen Screen of 5,000 combinations of FDA-approved drugs in the NCI-60 cancer cell line panel.

The analysis of a first combination screen supported a view of a mostly linear signaling pathway topology downstream of oncogenically activated EGFR/ERBB2 kinases [19].

This "combination screen" was identical to a standard F2 screen with the exception that the crosses were designed to identify synthetic lethal interactions with Smn in the F1.

The >3000 combination screen of the mating of 52 HCMV Gal4 DNA-binding and 59 HCMV Gal4 activation domain fusion proteins revealed 79 positive interactions among 37 virion proteins (Supporting Information Table S2 and Figure 3).

We performed a combination screen in a panel of 31 breast cancer cell lines to evaluate the synergism between the IAP inhibitor AZD5582 and TRAIL.

We performed a high throughput combination screen on a large panel of cell lines and searched for markers of sensitivity or resistance.

Zinner et al. developed another drug combination screening model called Medicinal Algorithmic Combinational Screen (MACS) and have screened 72 combinations of arbitrary size and formed a 19-element drug pool across four generations.

A new visualization technique for pairwise combination screening data, termed "Synergy Maps", is presented.

These methods include computational modeling, gene signature analysis, functional genomics, and high-throughput drug combination screening.

Hence, an improvement in chemical property representation for the visualization of compound combination screens is still very much desirable, which is the objective of the current work.

One of the major ongoing initiatives at the Developmental Therapeutics Program of the National Cancer Institute, U.S. National Institute of Health, is the large-scale high-throughput drug combination screening of 100 FDA approved drugs.