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In Section 5.5, the combination outcomes using average, median, and our method are compared.
The outcome variables were also prone to a large degree of variation in definitions and were grouped under six predefined domains: pain, disability, return to work, use of health care services or medication, global improvement and combination outcomes.
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We observe that the diversity rank-score graphs are good indicators for the combination outcome.
If the antibody combination outcome variable provided significantly improved fit as compared to the individual autoantibody outcome variables, then the combination was reported as the best fit model.
One low quality study included a mixed primary care population and found no association between ROM of the hip and a combination outcome of pain and disability [ 29].
One moderate quality [ 45] and one low quality study [ 33] found no association between SLR and a combination outcome of pain and disability.
The low quality study found an association with poor outcome of return to work and no association with a combination outcome of pain and disability in an acute population [ 33].
One high quality study including acute primary care patients reported on both short- and long-term outcome and found no association between percussion test and a combination outcome of pain and disability [ 65].
One study of moderate quality including acute patients from secondary care found a positive association between FFD and non-recovery (a combination outcome of pain and disability) however this was not sustained in a multiple logistic regression analysis [ 45].
Two studies found SLR to be predictive of poor outcome of disability [ 30, 61], one study found SLR to be predictive of poor outcome of use of health care services or medication, but the result was not retained in the final model [ 69], and one found SLR to be predictive of a combination outcome of pain and disability [ 29].
In this way, we leave it to readers to use their own priorities to decide whether any single outcome, or combination of outcomes, is the most important for their interpretation of the findings of MidU.
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