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The combination of two agents with different but complementary mechanisms of action is a logical approach for treating patients with type 2 diabetes.
The combination index (CI) was applied to quantitatively describe synergism defined as a greater-than-additive effect from a combination of two agents (CI<1), antagonism as a less-than-additive effect (CI>1), and an additive effect as (CI = 1).
The triple combination was more effective than the combination of two agents or a single agent.
Of these, 573 patients (91.5 %) used a single antimicrobial agent and 53 (8.5 %) used a combination of two agents.
In invasive aspergillosis, the combination of two agents (voriconazole plus echinocandin) is currently recommended only in salvage therapy for pulmonary aspergillosis.
32 The combination of two agents targeting different pathways involved in CML may significantly improve response rates and potentially increase survival.
Similar(45)
The geotextile was (1) exposed individually to each degradation agent (single exposure) and (2) exposed successively to some combinations of two agents (multiple exposures).
Even combinations of two agents at low concentration levels resulted in doubling of phospholipid levels (sertindole and trifluoperazine: 247±32 %, trifluoperazine and raloxifene: 250±45 %).
Using a 2-agent approximation we estimated the ORR of all combinations of two agents, provided the two agents were tested together, alone or in combination with other agents, in at least one clinical trial.
Microarray analysis shows that the triple combination activated the expression of a large set of genes to a much greater extent than either agent alone or the combinations of two agents.
The effects of these substances were synergistic, and the maximum effect was observed by combination of three agents.
More suggestions(15)
interaction of two agents
combination of two individuals
combination of two vices
combination of two technologies
combination of two methods
combination of two cultures
combination of two categories
combination of two logics
combination of two factors
combination of two algorithms
combination of two voices
combination of two sedatives
combination of two rights
combination of two buttons
combination of two modes
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com