The success of the series has created a new wrinkle for the staff: a sudden uptick in episodes means that the standards for finding subjects with the right combination of pathology and popular appeal may have to be loosened.
Second, in all studies a combination of pathology and follow-up was used as the reference standard.
The combination of pathology and genetics sets the rationale for appropriate clinical decision-making and possibly leads to improvement of outcome.
29 The combination of pathology-specific neuronal loss together with the preservation of neurons containing peptides involved in feeding regulation may have considerable clinical implications as targeted therapeutic interventions are developed.
Despite this, the case we are reporting describes a rare association between two aggressive neoplasms, and it will be helpful to clinicians who encounter similar combinations of pathologies.
11 Recruiting participants for combinations of pathologies such as amyloid, tau and/or genetic markers may increase the likelihood of near-term cognitive decline, consequently reducing sample sizes and trial costs.
Our aim in the present study was to examine whether a certain combination of these pathologies, or the prominence of a specific pathology, can explain the huge difference in life expectancy observed in AD.
Others suggest, however, that the neuropathological correlate of PDD is a combination of different pathologies rather than the severity of any single pathology [ 3].
However, the combination of such pathologies exerts additional detrimental effects that lower Crs even more dramatically.
Hence, the patterns we observe in C9ORF72 may be driven by a combination of these pathologies.
