The high frequency of "positive" results in our study sample could reflect a combination of multiple testing, selective reporting, and publication bias [ 14].
Due to the large number of all possible 2- and 3-SNP combinations tested, the issue of multiple testing should be addressed here.
In our study, combination of multiple mutation tests (KRAS or BRAF± PI3KCA) did not provide additional information over a single mutation test (data not shown).
Although the combination of multiple smear tests over three consecutive days resulted in the highest yield of smear microscopy (18 children), this approach required examining 1309 specimens and 237 hospitalization days.
However, the most reliable way to define primary and secondary dengue infection is based on a combination of multiple laboratory tests (virus isolation and/or detection of virus RNA by PCR, IgM and IgG antibody detection) performed on blood specimens collected at two time points, at least.
This approach is expected, therefore, to be affordable for routine diagnostic laboratories, with the benefit of a considerably more accurate identification of PNC than can be achieved using even a combination of multiple conventional tests.
The combination of cross-validation and permutation testing helps control the type I error rate in the presence of multiple testing.
The sticking point rests not with the standards, but with the ways in which we attempt to measure student learning through a combination of multiple-choice test items and short essays.
Moreover, extension of the latent class model can allow the combination of information from multiple tests to create a general cognitive factor that evolves over time [ 15].
The procedure is based on a nonparametric combination of multiple, possibly dependent, univariate permutation tests.
