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Each additional modification and each new combination of modifications represents an additional protein species of that single protein.
A combination of modifications (such as acetylation, methylation, phosphorylation, ubiquitination and sumoylation), within specific amino acids in each histone type leads to gene expression or inactivation [10].
If the current combination of modifications or (histone state) is "3-0-0-0-0" it cas be inthepreted as, the first amino acid (S1) is phosphorylated and the other amino acids (Table 1) are not modified.
Our GIP optimization strategy to design AC163794 focused on a combination of modifications that involved both the N- and C- termini of the GIP molecule.
The combination of modifications of resting ECG and SA-ECG identified all patients with prolonged HV interval (sensitivity 100% and specificity 75%).
Through altering the degree of chromatin compaction, PTMs of histone tails create chromatin structures favorable either for activation or repression of genes, depending on the genomic context and the combination of modifications at a given site [ 2].
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The optimal combination of modification for ideal plant shape and utilization of heterosis are an inevitable path for super-hybrid rice breeding.
All the elements of the battery are concerned and the solution, as we present herewith, is a combination of modification of the cathode, of the separator, of the electrolyte, including the choice of binder, even though few binder-free architectures have now been proposed.
The precursor peptides of these natural products are ribosomally produced, upon which a combination of modification enzymes installs diverse functional groups.
There is no simple one-to-one correspondence between the type of modification and the functional consequence, but rather the combination of modification type, enzymatic activity, affected residue and the DNA sequence in the immediate vicinity of the affected histone determine the functionality of the modification in a very complex manner.
Furthermore, the conclusion drawn by the analysis must take the power of the modification index test into account, which can be computed for every combination of modification index, EPC, δ and significance level alpha (which was fixed at alpha = 0.05 in this study).
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