Adherence and tolerability issues are probably more readily addressed than disease breakthrough because the combination of indication, posology and side-effect profile will often limit the choice of next-line therapy.
The main keys to success are a combination of proper indication, good technique, and an adequate rehabilitation protocol.
Importantly, the work required to establish the reliability and validity of a new biomarker should not be underestimated; it needs detailed planning for each combination of a clinical indication and a mechanism of action.
The majority of indications for the combination of endarterectomy either prior to, or at time of coronary artery bypass grafting were inappropriate.
In 2011 and 2012, 50 new drugs (excluding vaccines, combinations of known drugs, and extensions of indications) were centrally approved in Europe.
In the absence of a predictive molecular biomarker, treatments are selected using a combination of variables, including the licensed indication of the drug, which in turn can influence funding arrangements, and clinico-pathological factors relating to the patient and the disease biology.
Similar cases that were prosecuted, Comey said, involved some combination of intentional mishandling of classified information, indications of disloyalty to the United States, or efforts to obstruct justice.
13 The obstetrician's decision for a planned caesarean section is based on a combination of medical as well as psychological indications.
Research of the additional effects of HDAC inhibitors appears particularly important and promising, since both mouse data [ 2, 3] and ex vivo results [ 4] have given clear indications that a combination of demethylation agents with HDAC inhibitors may exhibit beneficial effects on the normal hematopoiesis as well as on active suppression of the malignant clone.
The combination of SSRI and sedatives/hypnotics gave no indications of an increased risk compared with either drug group.
