Crohn's disease, a chronic inflammatory disorder of the gastrointestinal tract, is thought to result from the combination of effect of environmental factors and genetic predisposition [ 66, 67].
However, when a mechanism is less understood or is a combination of effect mechanisms, it will be more challenging to make translational predictions and simpler approaches should be adopted that rely on fewer assumptions.
Characterization factors (CFs) were calculated as a combination of effect (EF) and fate factor (FF, relating water consumption to wetland area loss) (eq 4) for each taxon p and for each wetland k.
22 An improvement in single-word intelligibility of greater than or equal to 14% was deemed to be an MCID 22 based on a combination of effect size and SLPs' observations of functional improvements in intelligibility skills.
Results of 10,000 simulations per scenario with a standard deviation equal to 40% of the control mean, for each combination of effect size (0.2, 0.5, and 0.8 standard deviation units), number of patients (10/10 and 100/100 experimental/control patients per trial), and number of trials (5, 10, and 30) assuming a skewed distribution described in the Methods.
Results of 10,000 simulations per scenario with a standard deviation equal to 40% of the control mean, for each combination of effect size (0.2, 0.5, and 0.8 standard deviation units), number of patients (10/10 and 100/100 experimental/control patients per trial), and number of trials (5, 10, and 30).
