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Mixture exposure: The combination of doses received by a receptor from exposure to a mixture.
Preliminary observations and some apparently conflicting results reported in the literature led us to test the possibility that a combination of doses could yield better analyses.
A combination of doses of each chemical, which on its own did not produce statistically significant AGD alterations, induced half-maximal mixture effects.
Among MCF 7 cells the combination reaches an additive effect in higher dose ranges, whereas the combination of doses lower than the IC50 shows an antagonistic effect.
The best effects were observed in FLT3-ITD cell lines when both drugs were administered simultaneously, with CIs of 0.77 and 0.41 at a combination of doses that effectively blocked 90% of cell proliferation (ED90) for MOLM-13 and MV4-11, respecTabley (Table 1).
Conversely, the 9.5 DRI value for 1 α,25(OH)2D3 indicates that at this combination of doses, the presence of IR allows for almost a 10-fold decrease in the level of 1 α,25(OH)2D3 to achieve the same therapeutic effect.
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"There is always some consideration for dose, but it is a combination of dose plus susceptibility that sets the risk.
Understanding the conditions (i.e., the specific combination of dose level, homeostatic capacity, etc).
It is not known at what combination of dose level and frequency saturation of elimination begins to occur.
The study comprised of Cohort 1 evaluating a combination of dose levels and routes of administration and of Cohort 2 evaluating further optimized dose levels that were to be determined after a scheduled interim analysis.
The combination of dose intensive weekly cisplatin plus daily low-dose VP16 induced significant myelosuppression with leuko- and granulocytopenia, which necessitated dose delays of 1 2 weeks in 18 patients.
More suggestions(15)
combination of effects
combination of pesticides
combination of injections
combination of formulations
combination of exposures
combination of opiates
combination of rates
combination of times
combination of directions
combination of dosage
combination of methods
combination of letters
combination of factors
combination of things
combination of talents
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