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To date, comprehensive BRCA1 and BRCA2 mutation screening (using a combination of conformation sensitive capillary electrophoresis and multiplex ligation-dependent probe amplification) has been carried out in 120 patients from the POSH cohort, 39 of which reported no family history of breast or ovarian cancer.
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A good sport performer has a combination of superior conformation, an appropriate temperament, a healthy physical condition and primed physiological mechanisms, and function for optimal fitness that keeps the horse performing well.
A second complementary approach, called "Maximum Occurrence" (MaxOcc), at variance with methods based on ensemble reconstruction, aims at finding the maximum percent of time that the system can spend in one given conformation and still be compatible with the experimental observations, when taken together with any optimized combination of other conformations.
Most of their data can be satisfied by a combination of two conformations by dramatically altering the position of M1 and the inner portion of M2 for the open conformation (personal observation).
ZDOCK systematically evaluates a huge number of docked conformations on a grid by using a combination of shape complementarity, electrostatics and statistical potential terms for scoring [39], and the search process is accelerated by the Fast Fourier Transformation FFTT) algorithm [11].
The prediction of elastic properties of a polymer must therefore consider more than a single combination of chain conformations.
The target proteins may interact with a specific Ca2+-CaM complex or with a combination of CaM conformations with a unique number of Ca2+ ions.
We apply a combination of the multiple conformation statistical thermodynamic approach and variational transition-state theory (VTST) to obtain dynamic multi-path rate coefficients (kMP-T-VTST and kMP-LH-VTST).
Analysis for variants was performed by polymerase chain reaction amplification of individual exons of the ABCR gene with flanking primers and a combination of single-strand conformation polymorphism, heteroduplex analysis, and high-performance liquid chromatography.
They were identified based on the nuclear ribosomal DNA internal transcribed spacer 1 (ITS1) region using a combination of Single Strand Conformation Polymorphism (SSCP) and DNA sequencing [44], [60].
The coding and neighbouring intronic regions were screened by a combination of single strand conformation analysis (SSCP) and heteroduplex analysis.
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