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Thus, the combination of BNP and BIVA measurements may represent a novel, but logical criteria for discharge and risk stratification.
The strongest predictor consisted of a combination of BNP with miR-30c, miR-221, miR-328, and miR-75, generating an AUC of 0.854 for distinguishing HFpEF from HFrEF.
We found the combination of BNP and BIVA measurement, helped to avoid unnecessary aggressive diuretic therapy, reducing the level of renal complications, especially in the early- and non-responder groups.
We propose that a combination of BNP levels and proteinuria might be used to individualize the administration of the amounts of fluid and to predict outcome in patients with severe burns.
Graphical representations of some of these examples are highlighted in Figure 3, with the strongest predictor consisting of a combination of BNP with miR-30c, miR-221, miR-328, and miR-375, generating an AUC of 0.854 for distinguishing HFpEF from HFrEF.
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The maximal benefit from biomarkers may lie in the multi-marker approach as evidenced by the Olmsted study which reported that the combination of increased BNP with CRP levels enhanced the ability to predict risk of death compared with standard risk factors for mortality in heart failure [ 61].
In predicting 6-month mortality from acute heart failure, Nunez and associates demonstrated the combination of CA-125 and BNP added prognostic value to that provided by BNP alone [90].
In predicting 6-month mortality from acute heart failure, Nunez and associates demonstrated the combination of CA-125 and BNP added prognostic value to that provided by BNP alone [ 90].
Based on these findings, we hypothesize that low levels of BNP in combination with increased levels of proteinuria reflect inadequate resuscitation due to increased capillary leakage and predict worse outcome in patients with severe burns.
In this prospective outcome study of patients with ACS, the presence of a significant MR had prognostic implications and provided independent information over that obtained from the combination of reduced LVEF, high BNP and clinical risk factors.
The French treasury backed a three-way combination of the major French banks BNP, Paribas and Société Générale, but only BNP and Paribas wound up merging.
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