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The E value describes the probability of the match resulting from chance (a lower value corresponds to a lower probability), and the bit score evaluates the combination of alignment quality and length (a higher value corresponds to a better alignment).The y axis of each diagram shows the negative log10 of the P value and the x axis shows the respective parameter value.
We computed d' in the same way for each combination of alignment and congruency, by calculating the normal-transformed hit rate (the proportion of times each participant said "same" when the ground truth was "same") and subtracting from it the normal-transformed false alarm rate (the proportion of times each participant said "same" when the ground truth was "changed").
It was possible that this combination of alignment and peak-calling resulted in a loss of the set of highly methylated Kaiso binding sites.
With a proper combination of alignment and transcript reconstruction tools, Alt Event Finder is capable of identifying novel splicing events in the human genome.
The Ensembl platform [ 32] used to map the MHC in zebrafish provides a combination of alignment data, genomic location, detailed transcript structures to compare functional domains of orthologous proteins, in conjunction with multi-species comparisons.
As each fusion detection tool has a specific combination of alignment and filtering approaches, results produced by each tool are only partially comparable with the others' (Carrara et al., 2013a, b).
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Second, we showed that using a combination of alignment- and pattern-discovery-based conservation analysis approaches significantly improves prediction when compared to using only one of the approaches.
This will involve the powerful combination of alignment-free methods to predict putative homologs in the orthologous gene locus and experimental methods to characterize the expression readout of the predicted homolog.
Over two experiments we develop two instructional analogies using a combination of structural alignment, progressive alignment, and hierarchical alignment.
However, the probabilistic and PCA approach enabled a more holistic evaluation of sensitivity, including identification of combinations of alignment parameters that most significantly contributed to kinematic and contact mechanics outcomes throughout the flexion cycle, and the predictive capability to estimate joint mechanics based on alignment conditions without requiring additional analysis.
This shows all possible combinations of alignment and congruency.
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