Using a combination of aberration-corrected electron microscopy, molecular dynamics simulations and density functional theory calculations, we attribute the observed phenomenon to basal slip on the shuffle set along ⟨1¯100⟩.
Finally, alerts generated by other more complicated combinations of aberrations might provide further enhancements.
The underlying assumption of applying regularization in this context is that a sample will not generally contain all theoretical subclones, defined by all possible combinations of aberrations.
As in the case with one subclone, we excluded simultaneous occurrence of different kind of aberrations (e.g. deletion and duplication) at the same locus in the same subclone (e.g. neutral LOH); however, the two tumor components were generated such that their aggregate signal contained all combinations of aberrations (e.g. deletion and duplication).
Furthermore, this combination of genomic aberrations suggests a therapeutic context for dual mTOR/PI3K inhibition.
Although tumours with this combination of genetic aberrations can be found in patients, phenotypically they are closer to the WT1-wild-type subset than the WT1/β-catenin mutant tumours (Gadd et al., 2012).
Although the precise combination of genomic aberrations is notoriously heterogeneous between patients (Wyatt et al, 2014), at diagnosis the most common events include rearrangements affecting ETS gene family members, mutations in the ubiquitin ligase SPOP, disruption to the PI3K antagonist PTEN and copy number gain of oncogenic transcription factor MYC (Taylor et al, 2010; Barbieri et al, 2012).
The combination of an aberration-corrected imaging system with a phase-shifting device could, however, deliver an instrument with strong contrast and high-resolution transfer characteristics.
Moreover, 11q-/13q proves to be the most common of all possible combinations of single aberrations.
It underscores how combinations of physiological aberrations may lead to inefficient carbon dioxide exchange related to intrapulmonary shunting of blood.
