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TB normally takes six months to cure using a combination of the antibiotics rifampicin and isoniazid, but when the bacteria becomes resistant to them a new combination is needed that is more expensive and involves longer treatment.
The paper argues that this combination is needed in order to be a possible new path creator in the region.
From Equation 6 we can see that in order to estimate the number of DPP, the distribution of absence/presence of all the treatments in the combination is needed.
Given the activity of single agents on mCRPC and the safety of the combination regimen in other solid cancers, further research on this combination is needed for patients with mCRPC (Santisteban et al, 2008).
However, further research exploring response to additional stressors, both alone and in combination, is needed to fully understand the adaptive role of the core aphid defensome vs. stressor-specific responses.
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Because an optimal antitumor response requires coordination of multiple immune, tumor, and microenvironment effector cells, novel approaches targeting distinct mechanisms of action likely in combination are needed.
Data on efficacy and safety of this combination are needed before address new recommendations.
Further studies that include the transection of other gustatory nerves singularly and in combination are needed to examine this possibility.
It is known today that at least 3 effective drugs used in combination are needed to treat tuberculosis while preventing development of drug resistance [ 3].
For example, if a study found that the daily occurrence of a particular multipollutant combination has stronger impacts on health than others, we might conclude that further studies of this combination are needed.
However, before being widely embraced, further clinical trials on prognostic and/or predictive biomarkers, alone or in combination, are needed to validate their clinical utility, and to realize the goal of personalized treatment for patients with HNSCC.
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