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Fluticasone furoate/vilanterol (FF/VI) is a novel once-daily (OD) inhaled corticosteroid/long-acting β2 agonist combination in development for chronic obstructive pulmonary disease (COPD) and asthma.
Amikacin Inhale is an integrated drug-device combination in development by Bayer HealthCare through a collaboration with Nektar Therapeutics, to improve clinical outcome in intubated and mechanically ventilated patients with Gram-negative pneumonia.
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In fact, he foresaw the central role of pleiotropy and gene combinations in development and evolution and laid the foundation for systems and network analysis in genetics and biology and now diseases, advocated in precision medicine programs.
Aclidinium/formoterol is a twice-daily (BID) fixed-dose combination (FDC) in development for chronic obstructive pulmonary disease (COPD).
For decades, agents or combination regimens in development for treatment of advanced or metastatic melanoma were, at best, able to demonstrate increased response rates or PFS but failed to improve OS 22. Ipilimumab was the first immunotherapy to demonstrate improvement in OS in this patient population with high unmet medical needs, changing the therapeutic landscape for this disease in early 2011.
The red complex bacteria (Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) have been implicated, either singly or in combination, in the development of various forms of periodontal diseases.
Amikacin Inhale (NKTR-061, BAY41-6551) is a drug-device combination in clinical development for adjunctive treatment of intubated and mechanically ventilated patients with Gram-negative pneumonia.
His particular genius was in discovering the American appetite for novelty, with thirty-one flavors in each store at any given time (not including plain old chocolate, vanilla, and strawberry) and new combinations always in development.
Finally, as "triple" combinations are in development, these trials will evaluate the potential of ICS to reduce exacerbations on top of dual bronchodilation.
Bishop [ 10] and Nicholoson and Fawcett [ 11] noticed a combination of delays in development of coordination and language disorders in children.
Although this makes for a crowded infant immunization schedule, it is anticipated that the number of injections at any given visit will be alleviated with combination vaccines currently in development.
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