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Median PFS was similar in the two treatment arms: 8.5 months with bevacizumab alone and 9.9 months for the combination (hazard ratio [HR] = 0.86, P = 0.58).
There was a significant prolongation of PFS from a median of 8.2 months with anastrozole to 14.6 months with the combination (hazard ratio = 0.55, 95% confidence interval = 0.32 to 0.94).
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The combination of hazard evaluation and risk analysis is an organized effort to pinpoint weaknesses in the design and operation of facilities that could lead to accidental or unintentional chemical releases, fires or explosions.
This combination of hazard, exposure, and vulnerability combines to define the nature of risk.
Disaster risk, by definition, is a combination of hazard and vulnerability, with different approaches taken to combine the two parameters depending on the theory adopted or the practice being pursued (Lewis 1999; Wisner et al. 2004, 2012; UNISDR 2009).
The multi-criteria analysis approach used in mapping areas at risk of flood required a combination of hazard map (slope, drainage, soil type and isohyet) and vulnerability map (population, sewer system density and UST).
To reduce critical infrastructure losses during volcanic eruptions, successful risk assessment and management - a combination of hazard, exposure and vulnerability assessments - is required.
The parameters used in the flood risk map include slope, drainage density, soil, rainfall, system of evacuation, demography and land use which are the combination of hazard and vulnerability require interpolations to allow their crossing.
Regardless, all of these are approached through the combination of hazard scenarios, which are identified according to the techniques of consequence assessment, with the corresponding probabilistic levels of occurrence.
For every metastasis site/PET parameter combination, the hazard ratio associated with the PET parameter was greater than one, although not all associations were significant.
Only slight (nonsignificant) increases in overall survival were seen with each combination therapy (hazard ratios: 0.86 0.96) over the staged single-agent arm (Seymour, 2005).
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