Sentence examples for combination for development from inspiring English sources

These experiments demonstrate that off-target metabolism of PR-104 can be avoided and identify the suicide gene/prodrug partnership of E. coli NfsA/SN35539 as a promising combination for development in armed vectors.

Because topotecan has a different toxicity profile from ME-344 in clinical trials, this was a rational combination for development.

A novel format was designed using the combinations for development of the lateral-flow strip, so as to enable the detection of pyrethroids and endosulfan on a single strip.

Although no formal comparisons were performed and the differences were small, the NEPA combination selected for development had numerically higher response rates than the multiday aprepitant regimen for all efficacy endpoints and time intervals.

In addition, we discuss the relative importance of these independent properties and their combination for the development of a kinase-specific predictor.

A high-risk combination for sepsis development and typical for the patients group was the quintet of wild-type homozygotes (P = 0.005), but the most common specific combination in the three studied groups was BPI A + LBP A + TLR A + HSP 70 A + IL-6 B. This combination also represented high risk for sepsis development (P = 0.016).

According to the 'believe the positive' rule applied in a combined cross tabulation of patients with SOFA scores of 10 or more at day 4 after ICU admission and/or IL-6 plasma levels of 230 pg/ml or more, we observed a sensitivity of 85.7% and a specificity of 86.7% of this combination for predicting development of abnormal dmCMAP.

The assessment of the value of controlling these factors, and their combination, for future developments requires support of biological testing in appropriate mechanistic models, but also imperatively demand confirmation in therapeutically relevant in vivo models for biodistribution, efficacy, and lack of off-target effects.

Our results highlight the irreplaceable role of in vivo testing of novel vaccine constructs together with adjuvants to select combinations for further development.

High-throughput screening techniques provide a unique solution to study in a short period of time the properties and potentialities of large amounts of metal alloys/catalysts combinations for the development of large capacity hydrogen storing hydrides.

It is only a question of time before a reasonable number of risky combinations for sepsis development and for poor outcomes can be determined [ 30].