Sentence examples for combination exert from inspiring English sources

It was important to demonstrate that the individual drugs within the 267/Dt combination exert benefits consistent with their individual mechanisms of action.

Furthermore, we show that these agents, alone or in combination, exert their effect on cell growth via retinoid receptor-independent mechanisms.

We report that these compounds in combination exert a variable antiproliferative effect across multiple breast cell lines, which is synergistic in SK-BR-3 cells and triggers cell signaling events not predicted by the activity of either compound alone.

Disease mutations in RPGR 1– 19, RPGR ORF15, or RID of RPGRIP1α 1, singly or in combination, exert distinct effects on the subcellular targeting, co-localization or tethering of RPGRIP1α1 with RPGR1 19 or RPGRORF15 in kidney, photoreceptor and hepatocyte cell lines.

Transgenic plants expressing AtNAS1 and Pvferritin simultaneously accumulated six times more Fe in the endosperm than WT plants, showing that this combination exerts a synergistic effect on Fe uptake and storage (Wirth et al. 2009).

The combination exerted a synergistic effect in increasing the number of activated DCs in the cervical draining lymph nodes and eradicated intracerebral GL261 glioma cells in the mice (Wu et al., 2007).

The combination indexes for LBH589 (e.g., 12.5 nM) and TRAIL (3.125 26 ng/ml) combination in the tested cell lines were <0.5 (Fig. 1C), indicating that LBH589 and TRAIL combination exerts synergistic effects on decreasing cell survival of pancreatic cancer cells.

In contrast, the combination exerted a reduction in P-ERK1/2 and P-AKT that was very moderate and tumor type specific.

Our drug combination exerted a synergistic inhibition of MMP2, MMP3, and MMP9 at both the transcriptional and translational levels (Fig.  5c and e).

Strikingly, the drug combination exerted a robust synergistic effect on the expression of all three methylation steps of H3K4 in both adenocarcinoma cell lines (Fig.  4).

In parallel, the combination exerted strong synergistic effects in vitro, and in a nude rat model for cervical cancer it significantly inhibited the formation of metastases.