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However, all three anti-CD20 antibodies including BM-ca did not show combination effects with cisplatin in this cell line.
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Golvatinib treatment showed a combination effect with lenvatinib in both models (Fig. 2a).
Furthermore, DAAP showed a therapeutic effect and a combination effect with etanercept when injected after arthritis onset in established CIA.
Additionally, we proved that DAAP has therapeutic effects and a beneficial combination effect with the TNF-α inhibitor on CIA.
The differential PD changes observed in patients on cediranib result from the combination effect with chemotherapy and gives insight into the effect of cediranib addition to chemotherapy.
However, it is noted in these previous reports that the ZD6474 treatment schedule is the key aspect for its combination effect with cytotoxic agents.
Therefore, we examined another immunosuppressant, FK 506, on the combination effect with Taxol. Figure 1B shows that no enhanced cytotoxic effect was observed in Hep3B, Hepa 1-6 and HA22T/VGH cells treated for 24 and 72 h.
This study was performed to evaluate the antiarthritic effect of DAAP and the combination effect with the tumor necrosis factor α (TNF-α) inhibitor in collagen-induced arthritis (CIA).
In order to investigate potential mechanisms, to explain the enhanced combination effect with TMZ, we used the growth inhibition data generated from our anti-tumour studies to guide our pharmacodynamic sampling times.
The use of stanol ester as control test model has been proven several times to induce cholesterol reduction (Raisio Benecol Ltd., unpublished results) and the concentration in this study was selected to exert sufficient but not the maximal response, enabling the possible combination effect with sesamin.
Synergistic combination effects correlated with higher levels of apoptosis as compared with cells treated with the single agent alone.
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