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Golvatinib treatment showed a combination effect with lenvatinib in both models (Fig. 2a).
Furthermore, DAAP showed a therapeutic effect and a combination effect with etanercept when injected after arthritis onset in established CIA.
Additionally, we proved that DAAP has therapeutic effects and a beneficial combination effect with the TNF-α inhibitor on CIA.
However, it is noted in these previous reports that the ZD6474 treatment schedule is the key aspect for its combination effect with cytotoxic agents.
The differential PD changes observed in patients on cediranib result from the combination effect with chemotherapy and gives insight into the effect of cediranib addition to chemotherapy.
In order to investigate potential mechanisms, to explain the enhanced combination effect with TMZ, we used the growth inhibition data generated from our anti-tumour studies to guide our pharmacodynamic sampling times.
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However, all three anti-CD20 antibodies including BM-ca did not show combination effects with cisplatin in this cell line.
Our findings provide a molecular basis for the combination effect seen with dietary components, and indicate that ATRA may be a beneficial food component for cancer prevention when combined with EGCG.
In other experiments, the combination effect of chemotherapy with CP/GEM and i.t.
Synergistic combination effects correlated with higher levels of apoptosis as compared with cells treated with the single agent alone.
To further address the combination effects, we combined CXCR7 depletion with fulvestrant, which showed a 35% enhancement in the antiproliferative effect of the combination compared with fulvestrant alone (Additional file 8: Figure S8).
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