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Exact(9)
Therefore, semi-mechanistic PKPD models developed based on in vitro single and combination experiments can be valuable to suggest suitable combination dosing regimens.
Combination dosing with empagliflozin did not significantly alter the effect on food intake of sibutramine or orlistat.
Tumour growth retardation varied significantly as a function of combination dosing time (P from log rank <0.005).
M6 cells were also significantly growth inhibited by UCN-01, gemcitabine (P = 0.02 for days one and three), and by combination dosing with gemcitabine and UCN-01.
The excellent efficacy of this combination dosing supports the original hypothesis of Liu et al. In this study 2DG was combined with STX140, a microtubule disruptor.
Given the complexity of feedback regulation, the use of individual pathway inhibitors to evaluate combination dosing regimens in vivo would be more desirable.
Similar(51)
Statistical analysis of the combination dose effect [ 24] demonstrated that combinational index (CI) values were less than 1, indicating perhexiline synergistically enhances the antitumor effect of lapatinib.
The companies say they will try to develop new drugs and new formulations of existing ones, like combination doses for children.
The tetanus and diphtheria vaccines, which are given in a combination dose with the pertussis vaccine in a shot known as Tdap, are close to 100 percent effective.
The annual cost of drugs corresponded to the weighted cost of each drug, based on a combination dose of each one.
Administration of bortezomib 24 h before 131I-MIBG had an antagonistic effect (CI > 1) upon the toxicity to both cell lines at all combination doses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com