However, this simple ranking for drug combinations does not allow for other drug properties, such as drug interactions at the blood CNS interfaces to be considered, and these factors may actually contribute to lack of, or in fact enhanced, CNS efficacy of specific drug combinations.
Two combinations do not allow any mating because all spores are the same mating type (either all MATa or all MATα).
In the case of the other patients, the combination of mutant alleles does not allow us to draw a conclusion as to the in vivo effect of the specific mutation which is still compatible with in vitro activity.
But even the combination of MRI parameters does not allow detection of all cases of the disease, which is why the results should always be interpreted in conjunction with a patient's clinical symptoms, the findings of other diagnostic tests, and not least of all the results of myocardial biopsy.
It is important to keep in mind that if combination therapy with synthetic DMARDs does not allow the treatment target to be achieved, it is impossible to disentangle which of the agents was insufficiently effective, precluding better usage of synthetic DMARDs.
It is important to note that although the flow chamber set-up described here is suitable to study the entire multi-step T cell extravasation across the BBB, the combination with time lapse imaging does not allow fast movements as observed during T cell tethering or rolling on the BBB to be recorded.
However, it does not allow the combination of drug and patient, or health professional and disease.
The ephemeral nature of vents, in combination with their strongly isolated nature, possibly does not allow for the evolution and distribution of specially adapted forms, like in the macro- or megabenthic size class.
Minimus also does not allow for weighted combinations of contigs.
When 𝒯 does not allow all parentage combinations, the parentage posterior probabilities Pr(N+(v i )| A, N) (Section 3.2) must be corrected accordingly.
