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Simultaneous targeting of Top1 and Top2 has shown promise for clinical management of cancer, although this combination displays systemic toxicities.
It also has the advantage over other gel-based methods that each selective primer combination displays a different subset of cDNAs, thus facilitating experimental replication of genome-wide expression patterns [ 13].
The PMX and CPT-11 combination displays a strong schedule-independent synergistic cytotoxic activity against pancreatic cancer, providing experimental basis for its clinical testing as salvage chemotherapy in pancreatic cancer patients.
After screening many cytokines using multiple hPBMCs to find interactions between TLR9- and STING-mediated signaling pathways (data not shown), we found that our combination displays potent synergism in the induction of IFN-γ, approximately 10- to 90-fold more than stimulation with K3 CpG or cGAMP alone (Fig. 1A).
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That is when the device is using a cross-screen combination display.
In order to determine if artemisinin and vincristin combination display a synergistic cytotoxic activity against P815 and BSR cells, the combination index analysis (CI) method was used.
Control cultures grown in serum-free conditions or Wnt-3A and sFRP-1 combination display loss of architecture and proliferation and increased apoptosis.
Carriers of the rs4149601 GG-genotype together with the rs2288774 CC-or CT-genotype, as compared to non-carriers of this combination, displayed significantly lower P-renin and borderline significance for systolic salt sensitivity (P = 0.06 0.08) whereas there was no significance in diastolic salt sensitivity and Nt-proANP (Table 3).
No other combination displayed any association with SLE.
A specific mito-nuclear combination displayed a strong interaction effect.
Specifically, cells selected with paclitaxel NSC23925 combination displayed similar Pgp expression level to their parental cells.
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