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We compared the treatment response of the patients receiving this combination to the patients who did not receive this combination (data not shown).
As expected, both inhibitors strongly reduced phosphorylation of AKT and ERK1/2 when used individually, however, the effects were additive when were used in combination (data not shown).
The results showed a similar gain in body weight of control and treated group of animals with NSC-124854 and TMZ alone or in combination (data not shown).
Furthermore, no significant differences in mouse body weight were found between the four groups following the 20 d treatment, and there were no obvious toxicities from the drug combination (data not shown).
Sequencing results were identical using either primer combination (data not shown).
This effect was observed with palmitate or oleate, either individually or in combination (data not shown).
Similar(37)
No migration was observed in PP or DD combinations (data not shown).
We detected a similar degree of Smad4 expression in treatment combinations (data not shown), but competitive inhibition would not necessarily change the total amount of Smad4.
Evaluation of all potential three-marker combinations (data not shown) also failed to show any improvement in performance in either sensitivity at 98% specificity or AUC.
After testing all five fragments and the full-length BPC6 protein in all possible AD- and BD-combinations (data not shown), we found that the fragment BPC6-ΔC is responsible for the homodimerization of the AtBPC6 protein (Figure 3A).
However, the FST values were within 0.011 0.024 for all combinations (data not shown), thus documenting a high rate of exchange of genetic material over these wide geographic distances, and no evidence for geographic segregation.
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